News
- A new FWF ESPRIT grant for Valentina
We are happy to announce that Valentina Sladky was awarded with one of the prestigious ESPRIT (Early-Stage Program: Research – Innovation – Training) grants by the FWF. In the next three years, she will investigate how polyploidization, the process in which a cell gains more than two complete sets of chromosomes, is regulated across and shapes… Read more: A new FWF ESPRIT grant for Valentina - Annual Lab RetreatThis year, we skipped the Alps and met with our team members from Vienna along the Danube in Maria Taferl at hotel Schachner for our annual lab retreat. Going totally green, we either travelled by train and some decided to go there by bicycle even. It was a very relaxing and stimulating event for all… Read more: Annual Lab Retreat
- Consequences of Chronic spindle assembly checkpoint activation
During her PhD, Gerlinde analyzed the consequences of chronic spindle assembley checkpoint activation in vivo and realued that differnt tissues are differently affected with fast proliferating cell types in the gastrointestinal tract of bone marrow, being most affected. Looking into causes and consequences upon MAD2 overexpression, she realized that delays in mitosis cause apoptosis that can be… Read more: Consequences of Chronic spindle assembly checkpoint activation - Extra centrosomes delay DNA damage-driven tumorigenesisWork initiated by a former post doc in our lab, Fabian Schuler, was brought to completion in a concerted effort by Vincent and Gerlinde, now published in Science Advances. In their work, they could show that extra centrosomes, frequently seen in human cancer can become toxic to primary cells and promote cell death. This phenomenon… Read more: Extra centrosomes delay DNA damage-driven tumorigenesis
- Centrioles are frequently amplified in early B cell development but dispensable for humoral immunityWe are happy to report that Marina´s PhD work on the dynamic regulation of centriole numbers in developing B cells has now been published. Using different genetic models she noted that early progenitor B cells accumulate centrosomes that are then cleared and no longer detectable in mature B cells. Surprisingly, loss of centrosomes abrogates B cell… Read more: Centrioles are frequently amplified in early B cell development but dispensable for humoral immunity
