During her PhD, Gerlinde analyzed the consequences of chronic spindle assembley checkpoint activation in vivo and realued that differnt tissues are differently affected with fast proliferating cell types in the gastrointestinal tract of bone marrow, being most affected. Looking into causes and consequences upon MAD2 overexpression, she realized that delays in mitosis cause apoptosis that can be blocked by BCL2 overexpression or loss of the BCL2 family protein BIM, in a rather tissue dependent manner. This work has been published earlier this year in EMBO reports. Read more…
